COVID-19

PrimeStore® MTM - A novel viral transport media for infectious diseases


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Key features



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Test for COVID-19 and flu from the same sample swab


PrimeStore® MTM is a molecular transport media that gives the user a “snapshot” in time for that sample by preserving and stabilizing DNA and RNA.

 

PrimeStore MTM (Molecular Transport Medium) was designed and optimized for molecular testing allowing pathogenic samples to be collected, transported, and processed safely and efficiently. Millions of tubes of PrimeStore MTM have been sold to clients around the world during the SARS-CoV-2 pandemic.

 

The molecular transport medium inactivates infectious biological pathogens including viruses, and gram-positive/negative bacteria whilst preserving and stabilizing labile DNA and RNA for downstream molecular applications.

 

Viral transport media (VTM) were designed for transporting samples intact to be cultured prior to the widespread use of molecular testing and contain ingredients that inhibit optimal molecular testing. In contrast, PrimeStore MTM was invented and optimized specifically for molecular testing.

As the only FDA Class 2 cleared product for microbial nucleic acid storage and stabilization, hospitals and laboratories trust that PrimeStore MTM provides safer and more reliable testing than UTM/VTM, saline, or research use only devices.  

 

Laboratories have independently validated PrimeStore MTM with a range of platforms such as Roche, Thermo Fisher, Abbott, Siemens, Luminex, Bio-Rad, PSS, Promega, and BioMerieux, as well as the Cepheid GeneXpert point of care platform.

 

A key feature of PrimeStore MTM is that it allows lab teams to process multiple tests from a single sample that has been inactivated and stabilized in PrimeStore MTM.  

 

There are multiple peer-reviewed scientific papers, dating from 2011 onwards, supporting the use of PrimeStore MTM for pathogen detection from a wide range of clinical matrices and biofluid types collected and processed in different countries. A selection of these can be found below.

Antibacterial effectiveness testing, cert. USP 32-NF 27<51>

 

Bacteria and fungi

 

Organism

Positive control

(cfu/mL)

PrimeStore MTM + Organism

(% killed)

E. coli

6.4 x 107

100

S. aureus

6.0 x 107

100

MRSA

4.7 x 106

100

Viruses

 

Organism

Positive control

(TCID50/mL)

PrimeStore MTM + Organism

(% killed)

Influenza A (H3N2)

7.5 x 108

>99.99

Adenovirus type 5

7.5 x 108

>99.99

Influenza A (H5N1)

7.5 x 107

>99.99

*Initial 4-log dilutions of PrimeStore MTM + viruses were required due to PrimeStore lysis of tissue culture.

 

Stability of Influenza A RNA in PrimeStore MTM

 

PrimeStore MTM Stability Influenza molecular transport media-1.jpg

PrimeStore MTM Influenza Stability molecular transport media-2.jpg

Unlike most sample collection systems PrimeStore MTM alleviates cold chain requirements for sample collection and transportation, ensuring RNA stability for 7 days at ambient temperatures or 28 days at 2-8C.

 

Long-term frozen storage

 

PrimeStore MTM H1B1 molecular transport media.jpg

The PrimeStore MTM collection tube is optimised for short, medium- and long-term storage as samples placed in PrimeStore MTM are ready for biobanking with no requirements for additional supplies.

Studies


  1. Daum, L., Worthy, S., Yim, K., Nogueras, M., Schuman, R., Choi, Y. and Fischer, G., 2010. A Clinical Specimen Collection and Transport Medium for Molecular Diagnostic and Genomic Applications. Epidemiology and Infection, 139(11), pp.1764-1773.
  2. Dewar, R., Baunoch, D., Wojno, K., Parkash, V. and Khosravi-Far, R., 2020. Viral Transportation in COVID-19 Pandemic: Inactivated Virus Transportation Should be Implemented for Safe Transportation and Handling at Diagnosis Laboratories. Archives of Pathology & Laboratory Medicine,.
  3. Lorusso, A., Calistri, P., Mercante, M., Monaco, F., Portanti, O., Marcacci, M., Cammà, C., Rinaldi, A., Mangone, I., Di Pasquale, A., Iommarini, M., Mattucci, M., Fazii, P., Tarquini, P., Mariani, R., Grimaldi, A., Morelli, D., Migliorati, G., Savini, G., Borrello, S. and D'Alterio, N., 2020. A “One-Health” Approach for Diagnosis and Molecular Characterization of SARS-CoV-2 in Italy. One Health, 10, p.100135.
  4. Omar, S., Peters, R., Ismail, N., Dreyer, A., Said, H., Gwala, T., Ismail, N. and Fourie, P., 2015. Laboratory Evaluation of a Specimen Transport Medium for Downstream Molecular Processing of Sputum Samples to Detect Mycobacterium tuberculosis. Journal of Microbiological Methods, 117, pp.57-63.

References


  1. EKF secures COVID-19 novel sample collection kit manufacturing and supply contracts 

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