Central Laboratory : Clinical Chemistry : Glycated Serum Protein

Glycated Serum Protein LiquiColor Assay


An introduction to Glycated Serum Protein

EKF Diagnostics’ Glycated Serum Protein (GSP) LiquiColor® Assay offers a two to three week indicator of average blood glucose. This closes the information gap between daily glucose levels and quarterly HbA1c testing. 

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Superior specificity and accuracy

Glycated Serum Protein serves as an accurate intermediate marker of glycemia in instances where HbA1c may be of limited value such as pregnancy, reduced RBC lifespan and hemodialysis. 

The difference between actual measured HbA1c and predicted HbA1c from glycated serum protein is called the glycation gap. Measuring HbA1c and GSP together offers improved diagnostic accuracy by more reliably predicting complications of diabetes including nephropathy and retinopathy.

GSP provides superior specificity and accuracy compared to fructosamine assays (NBT method) for monitoring and assessment of short-term to medium-term (past two to three week period) average blood glucose levels. It is complementary to HbA1c in diagnosis and screening of diabetes.

Studies suggest that combining GSP results with HbA1c measurements provides a better assessment of the long term risk of diabetic complications. 


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Methodology Correlation to predicate method Linearity On-board stability* Calibration Sample type Sample size*

N = 65

R2 = 0.9966

Slope = 0.9542

Y intercept = 14.567

Range of values = 60-1249 µmol/L GSP

21.0 to 1354.0 µmol/L

Four weeks at 2 – 8ºC

Two point

Sold separately

Serum 10 µL

* Analyzer dependent

Within run precision


  Control level 1 Control level 2 Serum level 1 Serum level 2
N 80 80 80 80
Mean (µmol/L) 204 751 251 373
SD (µmol/L) 2.2 4.9 1.9 2.4
CV (%) 1.1% 0.7% 0.8% 0.6%

Total precision


  Control level 1 Control level 2 Serum level 1 Serum level 2
N 80 80 80 80
Mean (µmol/L) 204 751 251 373
SD (µmol/L) 2.4 5.6 3.2 3.7
CV (%) 1.2% 0.7% 1.3% 1.0%